BIOL 53700 Spring 2013: Immunobiology

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Schedule
:

The schedule is subject to change; please check for updates.

DATE

TOPIC

READING/CASE STUDIES

1/8

Immune system & its evolution

Smallpox vaccine

Ch. 1

Jenner (recommended)

1/10

Anatomy of the immune system

Congenital asplenia

Ch. 1

Case 1 (5th) / 30 (6th)

1/15

Course of immune response, inflammation

 

Hereditary periodic fever syndromes

Ch. 11 [11-1:11-12],

Ch. 7 [7-1:7-6, 7-19:7-23]

Case 7 (5th) / 34 (6th)

1/17

Innate immunity (first response)

Complement in West Nile infection

Hereditary angiodedema

Factor I deficiency

Deficiency of the C8 complement

Ch. 2

Mehlhop

Case 4 (5th) / 31 (6th)

Case 5 (5th) / 32 (6th)

Case 6 (5th) / 33 (6th)

1/22

Innate immunity (induced responses)

Leukocyte adhesion deficiency

IFNgR deficiency

Herpes simplex encephalitis

Ch. 3

Case 3 (5th) / 27 (6th)

Case 21 (5th) / 24 (6th)

Case 28 (6th)

1/24

Antigen presentation

MHC class I deficiency

MHC class II deficiency

Ch. 6

Case 17 (5th) / 12 (6th)

Case 18 (5th) / 8 (6th)

1/29

T cell receptor

 

Toxic shock syndrome

Ch. 4 [4-10:4-19],

Ch. 5 [5-9:5-11]

Case 26 (5th) / 47 (6th)

1/31

T cell development

Omenn syndrome

Ch. 8 [8-7:8-14]

Case 16 (5th) / 7 (6th)

2/5

T cell selection

DiGeorge syndrome

APECED

Ch. 8 [8-15:8-22]

Case 9 (6th)

Case 38 (5th) / 17 (6th)

2/7

T cell selection/tolerance

 

Discovery of tolerance

IPEX

Hemolytic anemia

Ch. 8 [8-15:8-22],

Ch. 9 [9-13:9-9-14]

Billingham

Case 25 (5th) / 18 (6th)

Case 39 (5th) / 41 (6th)

2/12

T cell signaling

Lepromatous leprosy

Ch. 7 [7-7:7-15, 7-17:7-20]

Case 30 (5th) / 48 (6th)

2/14

Mystery

Innate immunity, T cells

2/19

EXAM 1

[through T selection/tolerance]

2/21

T cell mediated immunity

 

Acute infectious mononucleosis

Wilskott-aldrich syndrome

Ch. 8 [8-23:8-26, 8-29]

Ch. 9

Case 27 (5th) / 45 (6th)

Case 22 (5th) / 16 (6th)

2/26

Immunoglobulin structure and function

Discovery of antibody structure & function

Ch. 4 [4-1:4-9]

Edelman, Porter

2/28

B cell diversity

Discovery of somatic recombination

Ch. 5 [5-1:5-8]

Hozumi

3/5

B cell diversity

X-linked hyper IgM syndrome

AID deficiency

Ch. 5 [5-12:5-20]

Case 11 (5th)

Case 12 (5th) / 3 (6th)

3/7

B cell development

X-linked agammaglobulinemia

Ch. 8 [8-1:8-6]

Case 10 (5th) / 1 (6th)

3/12

SPRING BREAK

 

3/14

SPRING BREAK

 

3/19

B cell mediated immunity

 

 

Influenza universal epitope

CD40 ligand deficiency

Ch. 7 [7-16],

Ch. 8 [8-27:8-28]

Ch. 10

Ekiert

Case 2 (6th)

3/21

Mucosal Immunity

Celiac disease

Crohn’s disease

Ch. 12

Case 36 (5th) / 44 (6th)

Case 39 (6th)

3/26

Immunological memory

Vaccines

Immune evasion

Pandemic flu of 1918

Ch. 11 [11-13:11-19]

Ch. 16 [16-19:16-31]

Ch. 13 [13-1:13-6]

Kobasa

3/28

Tumor immunology

Targeting tumor-associated macrophages

Ch. 16 [16-13:16-18]

Luo

4/2

Jeopardy

Mechanisms of Immunity

4/4

EXAM 2

[through B cell mediated immunity]

4/9

Cancers of the immune system

Failure of immunological synapse in AML

Multiple myeloma

T-cell lymphoma

Ch. 7 [7-30:7-32], 5th ed., see handout

Le Dieu

Case 19 (5th)

Case 20 (5th)

4/11

Transplantation

Graft-verus-host disease

Hemolytic disease of the newborn

Kidney graft

 

[TERM PAPER DUE]

Ch. 15 [15-29:15-38]

Case 47 (5th) / 11 (6th)

Case 45 (5th) / 46 (6th)

Case 46 (5th)

 

 

4/16

Immunodeficiency

HIV: Berlin Patient

X-linked SCID

Adenosine deaminase deficiency      

HIV

Ch. 13 [13-7:13-36]

Hutter

Case 14 (5th) / 5 (6th)

Case 15 (5th) / 6 (6th)

Case 31 (5th) / 10 (6th)

4/18

Allergy and hypersensitivity

Acute systemic anaphylaxis

Allergic asthma

Drug-induced serum sickness

Poison Ivy

Ch. 14

Case 32 (5th) / 49 (6th)

Case 33 (5th) / 50 (6th)

Case 35 (5th) / 52 (6th)

Case 37 (5th) / 53 (6th)

4/23

Autoimmunity

Multiple sclerosis

Lupus

Ch. 15 [15-1:15-28]

Case 44 (5th) / 40 (6th)

Case 43 (5th) / 37 (6th)

4/25

Review

 

TBD

FINAL EXAM

 




Last modified: January 6, 2013