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Peer Reviewed Papers

Parikh, M.R., Belch, A.R., Pilarski, L.M., Kirshner, J.  A Three-Dimensional Tissue Culture Model to Study Primary Human Bone Marrow and Its Malignancies. JoVE.  Accepted.


Zheng, M. M., Zhang, Z., Belch, A. R., Shively, J.E., Pilarski, L.M., Kirshner, J.  The Systemic Cytokine Environment Is Permanently Altered in Multiple Myeloma.  2013.  PLOS ONE.  8(3):e58504

Riofski, M. V., John, J. P., Zheng, M. M., Kirshner, J., Colby, D. A.  Exploiting the Facile Release of Trifluoroacetate for the a-Methylenation of the Sterically Hindered Carbonyl Groups on (+)-Sclareolide and (–)-Eburnamonine.   J. Org. Chem.  2011, 76(10):3676-83. [full text]

Gunn, E.J., Williams, J.T.,
Huynh, D.T., Iannotti, M.J., Han, C., Barrios, F.J., Kendall, S., Glackin., C.A., Colby, D.A., Kirshner, J. The Natural Products, Parthenolide and Andrographolide Exhibit Anti-Cancer Stem Cell Activity in Multiple Myeloma.  Leukemia and Lymphoma.  2011, 52(6):1085-97. [abstract]

Kirshner, J., Thulien, K.J., Belch, A.R., Pilarski, L.M.  In a Patient with Biclonal Waldenstrom Macroglobulinemia Only One Clone Expands in Three-Dimensional Culture and Includes Putative Cancer Stem Cells.  (2010).  Leukemia and Lymphoma.  2010, 52(2):285-9.  [Editor's pick]  [abstract]

Tancred, T.M., Belch, A.R., Reiman, T., Pilarski, L.M., Kirshner, J.  Altered Expression of Fibronectin and Collagens I and IV in Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance.  Journal of Histochemistry and Cytochemistry.  2009, 57(3):239-47.  [full text]

Kirshner, J.
, Thulien, K.J., Martin, L.D., Debes Marun, C., Reiman, T. Belch, A.R., Pilarski, L.M.  A Unique 3-D model for evaluating the impact of therapy on Multiple Myeloma.  Blood.  2008, 112(7):2935-45. [full text]

Chen, C.J.*, Kirshner, J.*, Sherman, M., Hu, W., Ngyuen, T., Shively, J.E.  Mutation Analysis of the Short Cytoplasmic Domain of the Cell-Cell Adhesion Molecule CEACAM1 Identifies Residues That Orchestrate Acting Binding and Lumen Formation.  J. Biol. Chem.  2007, 282(8):5749-60.  [full text]

Kirshner, J.*, Jobling, M.F.*, Pajares, M.J., Ravani, S., Glick, A., Lavin, M.F., Kozlov, S., Shiloh, Y., Barcellos-Hoff, M.H.  Inhibition of TGF
b1 Signaling Attenuates ATM Activity in Response to Genotoxic Stress.  Cancer Research2006, 66(22):10861-69.  [Cover article]  [full text]

Kirshner, J., Hardy, J., Wilczynsky, S., Shively, J.E.  Cell-Cell Adhesion Molecule CEACAM1 is Expressed in Normal Breast and Milk and Associates with
1 Integrin in a 3D Model of Morphogenesis.  J. Molec. Histology.  2004, 35(3):287-99.  [abstract]

Schumann, D., Huang, J., Clarke, P.E., Kirshner, J., Tsai, S.W., Schumaker, V.N., Shively, J.E. Characterization of recombinant soluble carcinoembryonic antigen cell adhesion molecule-1.  Biochem. Biophys. Res. Commun.  2004:318(1):227-33.  [abstract]

Kirshner, J., Schumann, D., Shively, J.E.  CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis.  J. Biol. Chem.  2003, 278(50):50338-45. [full text]

Kirshner, J., Chen, C., Liu, P., Huang, J, Shively, J.E.  CEACAM1-4S, a Cell-Cell Adhesion Molecule, Mediates Apoptosis and Reverts Mammary Carcinoma Cells to a Normal Morphogenic Phenotype in a 3D Culture.  Proc. Natl.  Acad. Sci. USA2003, 100(2):521-26.  [full text]

Reviews and Book Chapters

Andarawewa, K.L., Kirshner, J., Mott, J.D., Barcellos-Hoff, M.H.  “TGFb: Roles in DNA Damage Responses”, in Transforming Growth Factor-Beta in Cancer Therapy.  Volume 2.  The Humana Press Inc. 
2007, ISBN: 1-58829-715-2.


Colby, D.A., Kirshner, J. Use of NFKB Inhibitors As Anti-Multiple Myeloma Agents. U.S. Patent no.61/346,223, provisional filing 05/18/10.

Kirshner, J. and Pilarski, L.M.  Method and Apparatus for Evaluating Therapeutics on Cancer Stem Cells.  Filed 10/29/2007 (based on provisional filing U.S. Patent no. 61/000,748).

Last modfied:  May 1, 2013